Perfusion machine keeps livers alive outside the body for a week

A surgeon connects the donor liver to the perfusion machine

The machine has been in development since 2015, and at the project's outset the system could keep removed livers alive for around 12 hours. With the study, the scientists showed that six of ten perfused poor-quality human livers, declined for transplantation by all centres in Europe, recovered to full function within one week of application of the machine. Pierre-Alain Clavien, Chairman of the Department of Surgery and Transplantation at the University Hospital Zurich (USZ).

The human liver is hooked to tubes in the machine that pumps oxygen-filled blood through it, as well as remove old blood from it.

The perfusion machine while in operation, with the liver in the white container at left.

Next steps: The researchers still have some way to go to prove that the invention can work in practice, and that livers stored this way would be safe when transplanted into patients. Experts in transplantation medicine have hailed this new study.

In addition the machine that perfuses the organs outside the body could be used to bring to life injured livers from cadavers after perfusing them for several days. Now the donated as well as damaged livers could be preserved for a seven day period. For example, a patient with liver cancer could have a healthy section of their liver removed, grown using the machine, and then reimplanted with the remaining cancerous liver removed. Liver as an organ is capable of regeneration.

Ollie Williams releases statement after leaving the Love Island villa
Turley wasn't picked, but when she confessed it was her and that Capaldi was her ex, the other Islanders were visibly shocked. Speaking about their romance, he added: "I've known her for years".

The researchers say the system could also offer new approaches to tackling a range of diseases.

Wyss Zurich institute led a project called the Liver4Life project. Prof. Philipp Rudolf von Rohr, Professor of Process Engineering at ETH Zurich and co-leader of the project said, "The biggest challenge in the initial phase of our project was to find a common language that would allow communication between the clinicians and engineers".

However, Clavien said the system would be used for livers initially stored on ice but deemed too poor quality for immediate transplantation, and that in future it may also be used to boost the quality of marginal livers. These livers had been refused by all centres across Europe due to their poor functional qualities. They noted that six of the livers, by the end of the week were fully functional and ready for transplant onto recipients.

The team found that all 10 livers lost weight during the course of the week and four deteriorated. Lab tests were positive, showing normal function, robust cellular energy and intact liver structure. When placed in the device for a a few days, these livers may regain full function.

The week-long storage, the researchers say, would not only increase the distance over which organs can be transported, but offers another crucial advantage: it gives damaged livers more time to fix themselves, boosting the number of livers that could be used for transplant, while allowing doctors to reject those that are unsuitable.

Related News:



Most liked

Trump ex-adviser Flynn seeks to withdraw guilty plea - court filing
Tuesday's filing by Mr Flynn's lawyers asked Judge Sullivan to postpone that sentencing date. He cooperated extensively with the government over the next year.

Bruce Springsteen's Son Sworn In As New Jersey Firefighter | Chuck Nowlin
Bruce Springsteen's son was sworn in as a firefighter on Tuesday with the Jersey City Fire Department, along with 15 others. Check out what's clicking today in entertainment.

Amazon in India: Jeff Bezos announces $1bn Indian investment
Although traders are optimistic about the outcomes of the probe, they said they will continue building pressure on the government. He paid floral tributes to Mahatma Gandhi at Rajghat in New Delhi soon after his arrival. 'Live as if you were to die tomorrow.

Penn Badgley's You Season 3 Announced by Netflix
Co-creators Sera Gamble and Greg Berlanti will be returning as executive producers, with Gamble also serving as showrunner. The first season originally aired on Lifetime before moving over to Netflix as a Netflix original in Season 2.

Jennifer Lopez Wants To 'Break The Mold' By Working With Female Directors
He will be the star performer at this year's Super Bowl, which is one of the greatest honors in the industry for a performer . The theme of that year's Met Gala was camp, and the attendees were encouraged to wear ridiculous clothing.

Microsoft CEO Satya Nadella voices concern over CAA
BJP's IT Cell chief Amit Malviya also said that BuzzFeed's "tripe" quoting Nadella had been busted by Microsoft's statement. He spoke about growing up in "multicultural India" and his immigrant experience in the United States that has shaped him.

Iowa girl, 4, left blind after weeks-long battle with the flu
Amanda said she couldn't stop her kid from being sick, but if she can save one kid, that's what she would like to do. This is because the predominant virus has been influenza B, which affects children more than adults.

Australian Open qualifying player collapses on court as bushfire smoke chokes Melbourne
Jakupovic walked off the court at the start of her coughing fit, before bending over and falling to her knees. Australian men's player Bernard Tomic complained of getting exhausted easily and breathing difficulty.

"Crisis on Infinite Earths, Part 5" Photos Released
Kevin Conroy portrays a version of Bruce Wayne of the future (his first time playing the character in real action). Not to mention, we are more nervous than ever about which characters will really bring it to life.

United Kingdom consumers banned from using credit cards to gamble
The consultation that led to the commission's decision included e-wallets, indicating that payment services such as PayPal will probably be included in the ban.

Iran Plans To Sue Trump Over Soleimani Killing
Around this same time, Russian Federation joined Iran in backing the Syrian government, which has retaken most of the country. He said Major-Gen Soleimani was a "legitimate military target" and the strike was a "legitimate act of self-defence".

Novartis to speed access to $10 billion heart drug via NHS deal
The drug will be studied through a population-level agreement. . "Novel collaborations such as this put patients at the fore-front of the most promising breakthroughs".

Food airdropped for bushfire-affected animals in Aus
Officials have dropped over 2,000 pounds of sweet potatoes and carrots in various colonies in the past week, Kean said . Of the 15 species in Australia, most have disappeared and are now considered threatened, the website says.

Iran Makes Arrests Over Accidental Downing Of Ukrainian Airliner
Iran's Foreign Ministry summoned the British ambassador on Sunday to protest what it said was his presence at an illegal protest. An Iranian film director who'd called for protests in Tehran's Azadi, or Freedom, Square is among those released.

Kathryn and James Murdoch Speak Out Against News Corp Climate Coverage
A News Corp spokesperson declined to comment on James and Kathryn Murdoch's statement to The Daily Beast . The public outburst comes as Australia has been hit by the worst fires in decades.