
Bale had to watch from the stands as Wales lost 4-1 to Spain in a friendly at the Principality Stadium on Thursday, with the 29-year-old suffering "muscle fatigue" after being substituted in Real Madrid's shock 1-0 defeat to Deportivo Alaves on Saturday. "I think his absence will affect Wales".
Both players look doubtful for the Nations League game against the Republic of Ireland in Dublin next Tuesday.
"It's unlikely at this point", Giggs told Sky Sports.
"It's nothing serious but obviously the closer we get to the game, we have to make a decision".
Paco Alcacer scored twice, with Sergio Ramos and Marc Bartra also scoring for the visitors, and Sam Vokes heading in for Wales.
Jay Ajayi: Eagles should have run more vs. Vikes
The other came on a 62-yard fumble return by defensive tackle Linval Joseph and kicker Dan Bailey made 3-of-5 field goal tries. In the last two games, including Sunday's game against the Vikings , Wentz has been sacked 12 times and fumbled three times.
Sam Vokes scored from a David Brooks cross in the 89th minute to give Wales some consolation at the Principality Stadium, where the hosts were playing for the first time since 2011.
"The disappointment for me was in the basics". Giggs would have known that Spain are a top class side, even when they field a second-string team in friendlies like this, but he would surely not have expected his players to be humbled as comprehensively as they were here.
"Spain move the ball quickly and have penetration".
"We showed some threat going forward in the end and that's what we wanted to do". But we know we've put on some good performances in Cardiff (City Stadium) as well.
He's impressed with three goals in eight games for Leeds so far this campaign and his chances of featuring for the national side have gone up following an injury to Welsh talisman Gareth Bale.
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