Invented a vaccine against HIV, which has worked on people

World AIDS day 2

The drug Ad26 showed a high success and safety in trials on healthy people, caused the right effect of the immune system and protected rhesus monkeys from a monkey virus combined, analog HIV. The experimental regimens tested in this study are based on "mosaic" vaccines that take pieces of different HIV viruses and combine them to elicit immune responses against a wide variety of HIV strains.

The study in monkeys took a similar approach to vaccination, but involved exposing the monkeys to HIV infection on a weekly basis for a period of 6 weeks to see if the vaccine was effective at preventing infection.

As a part of this study, the HIV vaccine was tested on three hundred ninety-three people.

Near about 1.8 million people get affected with HIV virus per year and almost thirty-seven million individuals are living with the virus globally.

The study was conducted in 2015-2016, and in July 2017, scientists told the world about the results. He explained that more data needs to come in from human trials to deem this as safe and protective against HIV infection.

Barouch disclosed support from the NIH, the Bill & Melinda Gates Foundation, and Janssen Vaccines & Prevention BV, and is a co-inventor on HIV-1 vaccine antigen patents that have been licensed to Janssen Vaccines & Prevention BV.

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In the 35 years of the HIV epidemic, only four HIV vaccine concepts have been tested in humans, and only one has provided evidence of protection in an efficacy trial in Thailand, which lowered the rate of human infection by 31 percent but the effect was considered too low to advance the vaccine to common use. The volunteers were also injected with the common-cold virus to boost their immune system once at the start of the trial and again 12 weeks later into the study.

Meant to provide broad protection from the many strains of HIV that are prevalent worldwide, the "mosaic" vaccine contains a patchwork of genetic sequences found among various HIV strains. This was announced in the scientific journal Lancet. The HIV-1 vaccine proved safe and is now set to go to the next phase, which will be conducted in 2600 women in Southern Africa in a trial called imbokodo, a Zulu word for "rock". These results lead the researchers to believe that it might also be effective against HIV. We thank the International AIDS Vaccine Initiative (IAVI) and the generous support of USAID and other donors; a full list of IAVI donors is available online.

Dr Michael Brady, medical director at the Terrence Higgins Trust, said it was early days for the vaccine but the signs were "promising".

Dr Brady added that in the meantime there were already tools that were effective for preventing the disease from spreading, such as contraception and treatments for HIV-positive people that prevent them from passing on the virus. The age of participants was of 18-50; all were healthy, and none of them had HIV. "But the data is promising and we are happy to report the immune response". "Only a clinical efficacy trial can determine if it can protect humans".

The hope is that it could offer much better protection against the nearly unlimited number of HIV strains found across the world.

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