Study links ibuprofen to infertility

Ibuprofen male infertility issue joins cardiac risk as painkiller concerns grow

In the men receiving ibuprofen, levels of luteinizing hormone were up, and the ratio of testosterone to luteinizing hormone dropped.

Researchers told CNN that, while these effects were reversible, they were unsure of whether there were long-term health effects associated with the prolonged use of ibuprofen.

Ibuprofen, a drug used to treat fever and pain, has been found to have a negative impact on the testicles of young men.

The study showed that the drug disrupted the production of male sex hormones.

Overuse of ibuprofen could lead to full-blown hypogonadism, which refers to low levels of testosterone and diminished functionality of the testicles.

While previous research had already demonstrated that foetal exposure to ibuprofen and other analgesics (like aspirin and paracetamol/acetaminophen) could be harmful, less was known about its potential effects on adult men.

The study - conducted by a team of researchers in Denmark and France - was placebo-controlled and recruited 31 healthy white males between the ages 18 and 35 years.

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Jiri Dvorak, the former chief medical officer of FIFA, warned in March 2017 of an alarming trend of painkiller use, notably Ibuprofen, among football players, as the drug does affect doping tests, The Guardian reported. The findings are newly published in the journal Proceedings of the National Academy of Sciences.

"So the take home message is do not abuse them, and take the smallest dose for the shortest period of time".

During the last few decades, many other similar painkillers have been associated with health risks such as Acetaminophen, which is a common household drug for the American population.

The new study isn't the first to suggest that ibuprofen has downsides. Tests showed their testosterone levels hadn't changed, although the testes weren't producing adequate levels. In the group, the men who took 600 mg of Ibuprofen (the equivalent of three tablets) twice a day developed a condition called compensated hypogonadism.

Dr Kristensen said: "Taken together these data suggest that ibuprofen induced a state of compensated hypogonadism - which occurred as early as 14 days and was maintained until the end of the trial at 44 days".

"People taking over-the-counter ibuprofen should not be concerned by this research".

"It is sure that these effects are reversible", Jégou told CNN. Until now, it has been primarily linked to adverse effects such as gastrointestinal bleeding, cardiovascular disorders and kidney damage.

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